Hydrochlorothiazide: The most typical indications and signs of overdose noticed in humans are These attributable to electrolyte depletion (hypokalemia, hypochloremia, hyponatremia) and dehydration ensuing from extreme diuresis.
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Generally, sodium is reabsorbed into epithelial cells of your distal convoluted tubule and pumped to the basolateral interstitium by a sodium-potassium ATPase, creating a focus gradient concerning the epithelial mobile and the distal convoluted tubule that promotes the reabsorption of h2o.
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Thiazides show up in human milk. Because of the possible for adverse results within the nursing infant, a decision ought to be designed no matter whether to discontinue nursing or discontinue the drug, considering the significance of the drug into the mom.
If digitalis has also been administered, hypokalemia may well accentuate cardiac arrhythmias. The diploma to which hydrochlorothiazide is eliminated by hemodialysis hasn't been proven. The oral LD50 of hydrochlorothiazide is bigger than ten g/kg in the two mice and rats.
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